Metsähallitus 1859-1934

Letters 1934..1934

Sir, With interest we read the editorial by Wolf on obesity as a renal risk factor [1]. We fully support the author’s view that overweight and insulin resistance, as mediators of renal risk, deserve attention not only in morbidly obese patients with overt insulin resistance, but also in renal patients with less severe obesity. Recent data from our group suggest that the impact of overweight and...

Dev123653 1850..1859

The eye has served as a classical model to study cell specification and tissue induction for over a century. Nevertheless, the molecular mechanisms that regulate the induction and maintenance of eye-field cells, and the specification of neural retina cells are poorly understood. Moreover, within the developing anterior forebrain, how prospective eye and telencephalic cells are differentially sp...

Dmd052290 1859..1866

Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic uptake of many drugs, and the evaluation of OATP1B1-mediated drug-drug interactions (DDIs) is emphasized in the latest DDI (draft) guidance documents from U.S. and E.U. regulatory agencies. It has been suggested that some OATP1B1 inhibitors show a discrepancy in their inhibitory potential, depending on the ...

Detlev Bronk, 1934

Dmd052704 1934..1948

To investigate the expression profiles of efflux transporters in human ocular tissues, quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemistry were used to obtain the relative mRNA and protein expressions of various efflux transporters in human ocular tissues. The cornea, conjunctiva, irisciliary body (ICB), retina and choroid, human corneal epithelial cell ...